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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRCmore about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRCA total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normaldiffered between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectalDifferent levels of gut microflora in healthy and CRC samples were identified.

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnosticbiomarker of colorectal cancer

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 278-285 doi: 10.1007/s11684-016-0453-z

Abstract:

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide.We aimed to find novel molecules as potential biomarkers for the early diagnosis of CRC.Of these proteins, 29 were significantly different between CRC and normal tissue.for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associatedTPM2 may be valuable for the early diagnosis of CRC.

Keywords： iTRAQ     secretome     colorectal cancer     TPM2    

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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract:

Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%–85% of CRCs expressRecently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC haveOur study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and CRCThus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR

Keywords： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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The Composition of Colonic Commensal Bacteria According to Anatomical Localization in Colorectal Cancer

Liuyang Zhao, Xiang Zhang, Tao Zuo, Jun Yu

Engineering 2017, Volume 3, Issue 1,   Pages 90-97 doi: 10.1016/J.ENG.2017.01.012

Abstract:

Colorectal cancer (CRC) is a multistage disease resulting from complex factors, including geneticaccumulating evidence suggests that the gut microbiota is a new and important player in the development of CRCImbalance of the gut microbiota, especially dysregulated gut bacteria, contributes to colon cancer throughIt is notable that the translocation of colonic commensal bacteria is closely related to CRC progressionCRC-associated bacteria can serve as a non-invasive and accurate biomarker for CRC diagnosis.

Keywords： Microbiota     Colorectal cancer     Luminal commensal bacteria     Translocation     Biomarker    

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Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma Article

Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer

Engineering 2023, Volume 26, Issue 7,   Pages 32-43 doi: 10.1016/j.eng.2022.08.016

Abstract:

Aberrant glycosylation is considered to be a hallmark of colorectal cancer (CRC), as demonstratedtotal, 116 N-glycans were identified that showed profound differences in expression among cancerIn comparison with healthy mucosa, the cancer cells showed an increase in α2-6 sialylation andIn comparison with cancer, the stroma showed lower levels of oligomannosidic and monoantennary NN-glycomic profiles of different cell types in CRC tumor and

Keywords： Colorectal cancer     Tumor     Porous graphitized carbon liquid chromatography mass spectrometry     N-glycomics    

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Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal Article

Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi

Engineering 2022, Volume 16, Issue 9,   Pages 210-219 doi: 10.1016/j.eng.2021.03.028

Abstract:

Colorectal cancer (CRC) is the third leading cancer globally.Metagenomics has been widely used to analyze the association between the gut microbiota and CRC basedon bacterial genus- or species-level comparisons, providing evidence of dysbiosis in CRC developmentis unable to provide strain-level information for understanding the individual role of a species in CRCHere, we used culturomics to isolate CRC mucosal samples and selected 158 Escherichia coli strains

Keywords： Colorectal cancer     Gut microbiota     Culturomics     Escherichia coli     Strain level    

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Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Article

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Engineering 2020, Volume 6, Issue 9,   Pages 1028-1034 doi: 10.1016/j.eng.2020.06.007

Abstract:

Gastric signet ring cell carcinoma (SRCC) and colorectal SRCC are the most aggressive histologicalpopulation-based study to analyze the metastatic patterns of SRCC and further estimate its contribution to the cancer-specificsurvival of gastric SRCC and colorectal SRCC.A total of 4055 patients with gastric SRCC or colorectal SRCC were included in our cohort.In summary, metastasis is a major contributor to cancer mortality in SRCC.

Keywords： SEER Program     Survival analysis     Signet ring cell carcinoma     Metastases     Colorectal cancer     Gastric cancer    

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Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 304-307 doi: 10.1007/s11684-007-0058-7

Abstract: It provides a powerful evidence for colorectal carcinoma gene therapy.

Keywords： control     therapy     influence     Survivin-1     colorectal carcinoma    

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Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

CAO Jie, LI Wanglin, XIA Jie, TANG Weibiao, WANG Hui, CHEN Xiwen, XIAO Huanqing, LI Yuyuan, CHEN Xiaoping, DU Hong, CHEN Shanming

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 147-156 doi: 10.1007/s11684-007-0028-0

Abstract: However, the expression and the role of the FHIT in the initiation and the development of the colorectalcancer (CRC) are poorly understood.colorectal adenoma and normal colorectal tissue by tissue microarray (TMA).FHIT-negative CRC.contributing to our understanding of the mechanism of colorectal carcinogenesis.
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Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRCCells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer Article

Ana Montero-Calle, Itziar Aranguren-Abeigon, María Garranzo-Asensio, Carmen Poves, María Jesús Fernández-Aceñero, Javier Martínez-Useros, Rodrigo Sanz, Jana Dziaková, Javier Rodriguez-Cobos, Guillermo Solís-Fernández, Eloy Povedano, Maria Gamella, Rebeca Magnolia Torrente-Rodríguez, Miren Alonso-Navarro, Vivian de los Ríos, J. Ignacio Casal, Gemma Domínguez, Ana Guzman-Aranguez, Alberto Peláez-García, José Manuel Pingarrón, Susana Campuzano, Rodrigo Barderas

Engineering 2021, Volume 7, Issue 10,   Pages 1393-1412 doi: 10.1016/j.eng.2021.04.026

Abstract:

Colorectal cancer (CRC) is the second leading cause of cancer related death worldwide.The 5-year survival rate of CRC patients depends on the stage at diagnosis, being higher than 80% whenCRC is diagnosed in the early stages but lower than 10% when CRC is diagnosed in advanced stages.Thus, we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess aA total of 103 proteins were identified as potential autoantigens specific to CRC.

Keywords： Autoantibodies     Diagnosis     Colorectal cancer     Exosomes     Tumor microenviroment     Humoral immune response    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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The first year follow-up after colorectal adenoma polypectomy is important: A multiple-center study in

Qin-Yan GAO, Hui-Min CHEN, Jing-Yuan FANG, Jian-Qiu SHENG, Ping ZHENG, Cheng-Gong YU, Bo JIANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 436-442 doi: 10.1007/s11684-010-0200-9

Abstract: The recurrence of colorectal adenoma (CRA) is high.

Keywords： colorectal adenoma     polypectomy     follow-up     recurrence     risk factor    

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Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient Article

Zi-Xian Wang, Yi-Chen Yao, Zong-Jiong Mai, Wu-Hao Lin, You-Sheng Huang, Ying Jin, Hui-Yan Luo, Dong-Sheng Zhang, Feng-Hua Wang, Feng Wang, Gong Chen, Pei-Rong Ding, Yun-Fei Yuan, Yu-Hong Li, Jin-Hua Huang, Zhi-Zhong Pan, Rui-Hua Xu

Engineering 2021, Volume 7, Issue 4,   Pages 526-533 doi: 10.1016/j.eng.2020.10.017

Abstract:

There is a lack of high-quality, large-scale, real-world evidence from patients with metastatic colorectalcancer (mCRC), especially in China.

Keywords： Metastatic colorectal cancer     Real-world evidence     Treatment pattern     Survival     Big-data platform    

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Title Author Date Type Operation

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnosticbiomarker of colorectal cancer

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Journal Article

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

The Composition of Colonic Commensal Bacteria According to Anatomical Localization in Colorectal Cancer

Liuyang Zhao, Xiang Zhang, Tao Zuo, Jun Yu

Journal Article

Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma

Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer

Journal Article

Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal

Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi

Journal Article

Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Journal Article

Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Journal Article

Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

CAO Jie, LI Wanglin, XIA Jie, TANG Weibiao, WANG Hui, CHEN Xiwen, XIAO Huanqing, LI Yuyuan, CHEN Xiaoping, DU Hong, CHEN Shanming

Journal Article

Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRCCells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

Ana Montero-Calle, Itziar Aranguren-Abeigon, María Garranzo-Asensio, Carmen Poves, María Jesús Fernández-Aceñero, Javier Martínez-Useros, Rodrigo Sanz, Jana Dziaková, Javier Rodriguez-Cobos, Guillermo Solís-Fernández, Eloy Povedano, Maria Gamella, Rebeca Magnolia Torrente-Rodríguez, Miren Alonso-Navarro, Vivian de los Ríos, J. Ignacio Casal, Gemma Domínguez, Ana Guzman-Aranguez, Alberto Peláez-García, José Manuel Pingarrón, Susana Campuzano, Rodrigo Barderas

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

The first year follow-up after colorectal adenoma polypectomy is important: A multiple-center study in

Qin-Yan GAO, Hui-Min CHEN, Jing-Yuan FANG, Jian-Qiu SHENG, Ping ZHENG, Cheng-Gong YU, Bo JIANG,

Journal Article

Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient

Zi-Xian Wang, Yi-Chen Yao, Zong-Jiong Mai, Wu-Hao Lin, You-Sheng Huang, Ying Jin, Hui-Yan Luo, Dong-Sheng Zhang, Feng-Hua Wang, Feng Wang, Gong Chen, Pei-Rong Ding, Yun-Fei Yuan, Yu-Hong Li, Jin-Hua Huang, Zhi-Zhong Pan, Rui-Hua Xu

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article